从小到大，简（吉娜·罗德里格兹 Gina Rodriguez 饰）都被奶奶阿尔巴（伊凡·科尔 Ivonne Coll 饰）如此教育着：一是肥皂剧才是包含了人生全部智慧的圣经，二是女孩要不惜一切代价保卫自己的贞洁。所以，尽管已经有了交往已久的未婚夫麦克（布雷特·戴尔 Brett Dier 饰），但简依然守身如玉。 让简没有想到的是，自己竟然怀孕了！原来，在误打误撞之中，简接受了人工授精手术，而这枚精子的主人，竟然是简的老板拉斐尔（贾斯汀·贝尔杜尼 Justin Baldoni 饰），更糟糕的是，简的母亲坚定的认为，自己的女儿是圣母转世。腹中孩子的去留成为了简目前需要面临的最大问题，她会做出怎样的选择呢？Jane is a religious young Latina who is a waitress in a hotel in Miami. Her life takes a big turn for the unexpected when her doctor (Dr. Luisa Alver) mistakenly artificially inseminates her during her checkup. Jane's mother Xiomara, who became pregnant with Jane at a very young age, is scared that Jane will be destroying her life by deciding to bring the baby to full term, while Jane's traditional religious Latina grandmother, Alba, encourages Jane to do what she chooses. The biological father is a married man named Rafeal Solano, who is a cancer survivor and a former playboy. He is the new owner of the hotel where Jane works, and was her former teenage crush. Petra, Rafael's amoral and scheming wife, learns of the mistake and plots her own agenda. Petra is also involved in an affair with Roman Zazo, Rafael's best friend, who is under investigation by Jane's police detective boyfriend, Michael, and who also deals with Jane's unexpected condition in his own way. Meanwhile, the doctor who inseminated Jane, Dr. Luisa Alver, who is Rafael's younger sister, is distraught over learning that her wife cheated on her and left her. Elsewhere, Rogelio de la Vega, a famous TV star and, unbeknownst to her, Jane's biological father, shows up to wanting to make contact with Xiomara, unaware of Jane's existence.
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