代号47（蒂莫西•奥利分特 饰）是一个利用基因技术制作的复制人，受雇于名为“The Agency”的组织进行刺杀活动，47是他颈背条码的最后两个数字，也是他的名字。因为卷入了政治阴谋，47在东欧遭到了国际刑警和俄国军队的双重追杀。在追查真凶的过程中，他遇上了一个致命的女人（欧嘉•克瑞兰蔻 饰）。杀手的冷酷无情渐渐被女人瓦解，但是生命也正在受到威胁……A gun-for-hire "Hitman" is a genetically-engineered, elite assassin known only as Agent 47 hired by a group known only as 'The Organization' is ensnared in a political conspiracy, which finds him pursued by both Interpol and the Russian military as he treks across Eastern Europe. But even 47 couldn't anticipate a "random equation" in his life exactitude: the unexpected stirrings of his conscience and the unfamiliar emotions aroused in him by a mysterious Russian woman.
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