梅尔（本·斯蒂勒 Ben Stiller 饰）是一名昆虫学家，他和妻子南希（帕特丽夏·阿奎特 Patricia Arquette 饰）之间的感情十分恩爱，最近，南希刚刚诞下了两人爱情的结晶，让整个家庭都笼罩在喜悦之中。然而，这个孩子的降生让梅尔开始思考起了自己的人生，梅尔自幼失去了父母，由养父母抚养长大，梅尔希望能够在有生之年里见一见自己的亲生父母。 就这样，不顾养父母的反对和阻挠，梅尔带着妻儿踏上了寻根之旅，和他们一起上路的，还有领养机构的工作人员蒂娜（蒂娅·里欧妮 Tea Leoni 饰）。蒂娜刚刚经历过一段失败的婚姻，此时的她整个人都处于一种饥渴的状态之下，而南希似乎患上了产后抑郁症。Mel Coplin departs on a mission of discovery dragging his wife and 4 month old son behind. He and wife, Nancy, won't agree on a name for their son until adopted Mel gets in touch with his roots. He assures her that once he knows who he really is, the right name for their boy will be a snap. Enlisting the aid of student-psychologist and part-time adoption agent, Tina Kalb, they embark on a journey across the United States to find Mel's "birth" mother. "The best part," Mel tells Nancy, "is it's all free." Tina is finishing her dissertation and will film the happy reunion of mother and child as part of her research. For this privilege, she's footing the bill. His adoptive parents are left behind feeling abandoned by an ungrateful son. Clerical errors, mistaken identities, Nancy's misplaced high school friend and his gay lover, and a super-charged libido here and there are thrown into the mix along the way until -- at last -- Mel's real parents, the Schlictings (mispronounced as "Shit-kings" by Mrs. Coplin), are discovered in remote New Mexico. There, Mel begins to wonder if he would have been better off not knowing these people, after all.
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