考古學家將暴君烏瑟卡拉的木乃伊運到紐約的一所大學,準備進行解剖。烏瑟卡拉生前被製成木乃伊後,還由巫師下封印,詛咒他永世不得超生。然而,這個封印被意外打開了。不料,大學的另一名瘋狂博士竟然私自買賣器官,秘密進行讓人體復活的醫學實驗。當復活的科學怪人遇上一心想復仇的木乃伊,誰勝誰負?In New York, the professor of the medical university Dr. Victor Frankenstein is buying body parts from the janitor Carter to build a corpse and reanimate it. The Egyptologist Naihla Khalil, from the same university, has just returned from an expedition and brought the Mummy of Usekara, an evil and cruel pharaoh that was cursed, leaving his soul trapped in his mummified corpse. Victor and Naihla have a crush on each other and they date. Meanwhile Professor Walton, who is chief of department where Naihla works, accidentally releases Usekara's soul and is possessed by him. He kills his assistant Isaac and his blood awakes the Mummy. Then Walton lures his student Lenora and the Mummy eats her heart. Frankenstein's monster is reanimated and Victor is surprised with his capacity. But soon both monsters want Naihla: Frankenstein's creature to force Victor to transfer his brain to a new body and the Mummy believes she is the sorcerer that trapped his soul and wants Naihla to call off the spell. What will happen to Naihla?