理查德博士（尤安•格瑞福德 Ioan Gruffudd 饰）的科学梦想即将实现！他将飞往宇宙风暴的中心，揭开人类基因的密码。同行的还有，项目赞助人冯•杜姆（朱利安•麦克马洪 Julian McMahon 饰）、宇航员本•格林姆（麦克•切克里斯 Michael Chiklis 饰）、博士的前女友苏•斯通（杰西卡•阿尔芭 Jessica Alba 饰）以及她弟弟约翰尼•斯通（克里斯•埃文斯 Chris Evans 饰）。 不料，飞船接近风暴中心时，由于计算错误，导致飞船被宇宙射线所吞没！大难逃生返回地球后，组员们的基因因宇宙射线的影响，发生了变异，他们具有了各个不同的超能力。 理查德、苏、约翰尼和本组成了“神奇四侠”，利用宇宙射线所赋予的超能力去打击黑暗势力、帮助世界。杜姆获得超能力后变身成为了“毁灭钢眼博士”，正在实施他的邪恶计划。神奇四侠出击了！
Plot Summary:Reed Richards, a brilliant but timid and bankrupt scientist, is convinced that evolution can be triggered by clouds of cosmic energy, and has calculated that Earth is going to pass one of these clouds soon. Together with his friend and partner, the gruff yet gentle astronaut muscle-man Ben Grimm, Reed convinces his conceited MIT classmate Dr. Victor Von Doom, now CEO of his own enterprise, to allow him access to his privately-owned space station. Von Doom agrees in exchange for control over the experiment and a majority of the profits from whatever benefits it brings. He thus brings aboard Susan Storm, his shy, though assertive chief genetics researcher and a former lover of Reed's with whom she had an acrimonious break-up, and her diametrically opposed brother Johnny, the maverick and hot-headed playboy pilot. The astronauts make it home intact; however, before long they begin to mutate, developing strange and amazing powers as a result of their exposure to the cloud! Reed is able to stretch like rubber; Sue can turn invisible and create force fields, especially when angered; Johnny can produce fire at supernova temperatures, and is able to fly; and Ben is transformed into "The Thing", a large, rock-like creature with super strength. After Ben, brooding about his situation on the Brooklyn Bridge, inadvertently causes a major traffic pile-up whilst attempting to stop a man about to commit suicide, the four manage to use their powers to prevent any loss of life and to rescue a fire truck and its crew from falling off the bridge in a resulting explosion. The media dubs the team the 'Fantastic Four', and whilst Johnny eagerly embraces his powers and new life, Ben - the most heavily disfigured - particularly suffers from his transformation; his disfigurement has caused his fiancée to abandon him and has seen him shunned and feared by much of New York. Blaming himself, Reed vows to return Ben to his human form, and he, Sue and Ben work on a cure, constructing a healing chamber in Reed's high tech Baxter Building loft-turned-laboratory. During this time, Reed and Susan begin to grow close once again, and Susan admits that she is not interested in Victor, but ended their relationship because Reed feared to commit, thinking only in terms of variables. Unknown to the others, however, Victor's body is also mutating; he is turning into organic metal capable of absorbing and manipulating electrical energy known as Doctor Doom. As a result of the disastrous expedition, his company is going bankrupt and he is losing public stature; blaming Reed for his misfortunes, Victor swears revenge. And Reed, Ben, Susan, and Johnny must defeat Victor Von Doom and foil his evil plans once and for all.
