在三位人妖大妈成功超渡古老宅院的怨女幽魂之后(顽皮鬼2),她们又受邀来到一座西式别墅。而别墅主人千叮万嘱,让前来驱鬼的大妈们千万不能靠近红色建筑。驱鬼行动于是开始,人妖大妈们却发现,这座别墅是一座男子公寓,里面住的不仅有年轻帅气的大学男生们,还有一位肌肉健硕的猛男。她们渐渐发现,这座别墅隐藏着很多秘密……After three katoey siblings (lady boys) have succeeded in freeing the ghost of an ancient lady in the previous sequel, they become famous and are now asked to run a haunted all-male apartment. More ghosts are waiting for these fun-loving katoeys and their cohort of amusing sidekicks.