沃诺斯(查理兹·塞隆 Charlize Theron 饰)童年的不幸把她推向了罪孽深重的人生。她的母亲离她而去,对待她的是无休止的谩骂和虐打。沃诺斯为了满足毒瘾和生计,十来岁就开始了卖淫的生活。她在公路上为司机们提供低级的性服务,无望的生活无穷无尽。然而,年轻女孩西尔比 (克里斯蒂娜·里奇 Christina Ricci 饰)的出现让她心中有了亮光,两人开始了一段恋情,住在一起。 西尔比对于金钱的需求很大,这使得沃诺斯心甘情愿为爱人奔波赚钱。她去面试了好几份工作,却因为知识的匮乏和粗鲁的男性化性格而被拒之门外。她只能重操旧业,在公路上遇见了一个变态的嫖客,一怒之下把他杀死,夺走了他的钱和车。从此,沃诺斯开始频频犯罪,成为公路上的心狠手辣的女魔头。The true story of serial killer Aileen Wuernos who was convicted of luring men to their death and eventually executed in 2002. In 1989, she was working as a prostitute and finally makes a friend when she meets and begins a relationship with a young woman, Selby. Determined to straighten out her life, she tries to find legitimate work but with little education and limited social skills, she fails at every turn. She starts working as a hooker hitching rides along the local interstate highway and after robbing a few clients has an encounter with a vicious client whom she kills in self-defense. After that however she just takes to killing clients taking their money and car. Once arrested she claims self-defense but is eventually convicted.