初涉社会的安德丽娅•桑切丝(安妮•海瑟薇饰)来到了著名时尚杂志《RUNWAY》面试,以聪明得到了主编米兰达•普雷斯丽(梅利尔•斯特里普)的特许,让她担任自己的第二助理。开始的时候安德丽娅感到十分委屈,就算自己多努力工作也无法得到赞赏,经一位老前辈的指点便重新改造自己。工作越来越顺,甚至取代了第一助理在米兰达心中的地位,决定带着这个聪明的女孩前往法国。可安德丽的改变让她失去了男友及朋友的爱,令她非常矛盾。 到达法国后,她得知了米兰达的地位不保了,没想到米兰达竟然牺牲自己多年的好搭档保住了自己的地位,此事令安德丽娅深感失望,有了抽身离去的想法,到底安德丽娅会何去何从?In New York, the simple and naive just-graduated in journalism Andrea Sachs is hired to work as the second assistant of the powerful and sophisticated Miranda Priestly, the ruthless and merciless executive of the Runway fashion magazine. Andrea dreams to become a journalist and faces the opportunity as a temporary professional challenge. The first assistant Emily advises Andrea about the behavior and preferences of their cruel boss, and the stylist Nigel helps Andrea to dress more adequately for the environment. Andrea changes her attitude and behavior, affecting her private life and the relationship with her boyfriend Nate, her family and friends. In the end, Andrea learns that life is made of choices.