20世纪60年代,美国的势力向亚洲渗透,为此政府实行的一项绝密计划——战士再造计划,通过药物注射等手段将士兵大造成冷血无情、实力强悍的超级战士。随着技术不断改进,在罗伯特·柯林博士的主持下又开启了白塔计划,成功打造出更为完美的第二代超级战士。然而一次意外后12名二代战士逃亡,而涉嫌叛国的柯林博士也被驱逐东欧。此后不久,再造战士占领切尔诺贝利,美国军方决定派出4名尚存的一代战士前去击垮那群危险怪物,但是他们全部遭到无情屠戮。 走投无路之际,军方只能派出第五名一代战士卢克·戴沃洛克斯(尚格·云顿 Jean-Claude Van Damme 饰)出马,对抗强大的对手安德鲁·斯科特(杜夫·龙格尔 Dolph Lundgren 饰)……With stolen top-secret technology, terrorists have created a next-generation Universal Soldier - an elite fighter genetically altered into a programmable killing machine. With this "UniSol" (Former UFC Heavyweight Champion Andrei "The Pit Bull" Arlovski) leading the way, they seize the crippled Chernobyl nuclear reactor, threatening to unleash a lethal radioactive cloud. The only one who can stop them is Luc Deveraux (Jean-Claude Van Damme), a UniSol who's been decommissioned for years. Reactivated and retrained, Deveraux must make a full-out assault on the heavily armed fortress. But inside, he'll discover not one but two of these virtually indestructible warriors. Andrew Scott (Dolph Lundgren), Deveraux's vicious UniSol enemy from the original Universal Soldier, has been secretly reanimated and upgraded. Now, these elite fighters are locked, loaded and programmed to kill; and the fate of millions hinges on this high-action showdown.