2005年8月29日,威力巨大的强台风卡特里娜即将袭击新奥尔良。在当地一家医院,男子诺兰·海斯(保罗·沃克 Paul Walker 饰)却迎来了人生的悲喜时刻。他刚刚迎来新出世的宝贝女儿,但美丽的妻子阿比盖尔(珍尼希斯·罗德里格兹 Genesis Rodriguez 饰)却在分娩过后撒手人寰。娇嫩的宝宝还无法适应全新的环境,只能被放在暖箱中依靠机器辅助求生。面对眼前完全陌生的小生命,诺兰和妻子一幕幕美好的回忆相继浮现眼前,令这个经历了重大悲喜变故的男人百感交集。 暴风雨渐趋强烈,医院人手不足,医患被迫紧急疏散,而垮塌的大坝更将灾难推向顶点。孤独的诺兰必须与时间和命运赛跑,用一己之力保护他在这个世上最后的亲人……In New Orleans just before Hurricane Katrina hits, a pregnant woman gives birth prematurely. She dies and her baby is in critical condition. The baby has to be kept in a neonatal incubator. When the hurricane strikes, all the power goes out and everyone in the hospital leaves. But the baby's father stays because the baby can't be moved so he has to take care of his baby by making sure the ventilator stays on. And because there's no power, the only power source is generator that he has to crank every few minutes. So he has to stay awake while waiting for someone to come for them.